Micky van de Ven Double Halts The Toffees' Run at Brand New Stadium
The Dutch defender emerged as the initial backline player to score twice in a Premier League game for Tottenham since the Belgian defender in March 2013.
Match summary
Micky Van de Ven heads into the net two times in first half
Everton's Jake O'Brien has goal disallowed after VAR review
Senegalese midfielder scores third in dying moments
This loss is the Merseyside club's first at Hill Dickinson Stadium
Micky van de Ven found the net twice as Tottenham extended their winning streak on the road in the top division and handed the Toffees their initial loss at Hill Dickinson Stadium.
The Toffees were unbeaten in their last five matches at their recently opened stadium at the dockside location, having left their historic home behind after 133 years at the conclusion of last season.
But Spurs captain the Dutchman pounced twice from corners in the opening 45 minutes to put their strong form at jeopardy, and they were unable to turn it around before Pape Matar Sarr - set up by former Toffees attacker the Brazilian - nodded in a final goal to seal the victory.
The Everton defender believed he had equalized the tally five minutes after Van de Ven's opener, directing a powerful header past the Spurs keeper from an Everton corner.
Beto, in the meantime, missed a number of opportunities, while the Italian goalkeeper made a series of excellent stops to guarantee the London club went five away games unbeaten in the Premier League.
But the video assistant referee intervened, advising Craig Pawson to review the score on the screen and the official decided that Jack Grealish and the attacker were in offside positions and had impeded with the Tottenham goalkeeper.
The win moves Thomas Frank's side up to third in the division, a handful of points off north London rivals and leaders Arsenal.
The Merseyside club stay in 14th position and sit six points ahead of the relegation zone.
Tottenham analysis: Van de Ven fulfils role at each end of pitch
Following a uninspiring midweek display in the European competition against the French side, where they managed a only two shots on target, Frank chose Randal Kolo Muani in attack instead of ex-Everton forward Richarlison.
The summer signing was failed to influence the game before being replaced for the substitute after 60 minutes on the pitch, but it emerged he proved unnecessary in the final outcome.
Defender Van de Ven transformed into an attacking force to be feared.
Tottenham's opening strike came from a cleverly executed corner routine, with Rodrigo Bentancur directing the ball toward the face of goal for an free Van de Ven to score.
And the captain - stepping up as captain in Cristian Romero's unavailability - added his next goal in added time as he outjumped Jordan Pickford to head home.
Van de Ven was just as impressive in defence, partnering well with Kevin Danso as the duo handled excellently with the numerous deliveries thrown their way by the opposition.
Everton analysis: Toffees missing finishing touch
Everton's new home had been a fortress, but it appears the freshness may have faded slightly and supporters headed to the gates after the midfielder's third for Tottenham.
The end in the team's winning streak at home will not be a massive worry for David Moyes, but their striker situation will be.
The forward and Thierno Barry - the Toffees' pair of recognised strikers - had scored just a single goal combined before Sunday's outing.
And they were failed to contribute to that miserable tally on a damp and dreary evening on in Liverpool.
The striker's form was epitomized when he opted to bicycle-kick a clear chance from close range, despite having space and opportunity to reposition for a more conventional attempt that would have challenged Vicario.
Barry, as well, failed to influence the game after replacing Beto in the 65th minute.
It wasn't for a lack of chance. Most of Everton's attacks came through the winger and Ndiaye, who relentlessly delivered dangerous crosses into the Spurs box.
Upcoming fixtures for these two sides?
The Toffees: The team head to Sunderland in the Premier League on early November at 8 PM.
Tottenham: Spurs travel to St James' Park on late October for their fourth-round League Cup tie against Newcastle.